Peptide Synthesis could be defined as a combination of Coupling Reagents and Protecting Groups in the Appropriate Solvent. Taking as a basis the Green Chemistry definition: ‘‘Design of chemical products and processes to reduce or eliminate the use and generation of hazardous substances,’’ in this presentation, we will review our last work focused on reducing the consumption of solvents. Furthermore, we will introduce some new solvents to be used in solid-phase peptide synthesis, coupling reagents, and additives as well.
|